I've only done one rally so I'm no expert, but I went for the bonii in areas that I was familiar with, which also happened to be some of the bigger values and stuff I wanted to see (historical stuff you usually don't take time to stop and see). In order to get a visual on the total distribution and value of the bonii, I plotted the bonii locations and stuck in circles with diameters/radii relative to the value of the points - that way it was pretty easy to see where the groupings of bigger bonii were. I can't remember which mapping program that was, but that simple symbol feature was nice.
The old rule of always leaving an 'out' if you fall behind is good. The rally I ran was in the cold rain which really sucked and I fell behind on the schedule and ditched some bonii along the route (altered the route) and dropped some of the last planned bonii. I planned my route with highways or major roads within 'jumping off' distance so I could catch up if needed - really kinda like a regular day trip where you wander around an area that you want to see and jump ship when you need to get home...
If I were to do the same rally today, I would head for the totally unknown bonii locations and take my time. So, the final answer is "It Depends".

M-