A nice road to enjoy. IIRC it doesn't have much of any pref as for one direction being more enjoyable over the other. One item that I vaguely recall - the western slope of the road has some short sections that are 1.5 lanes wide where cars/trucks have to take turns, a fun curiosity. You might wish to plan 20-40 minutes at the Independence Pass lookout.
Google Map - Independence Pass / lookout to the expansive valley to the easthttp://goo.gl/maps/c65wz
Panorama photo from the lookouthttp://www.jimwilliamson.net/motorcycle/2003-08-co-trip/d4-tue/img-pan1-lg.jpg
From Carbondale through Aspen - something you need to slog through. Might well be police around.
If you have the time, the Maroon Bells (in the top three "Colorado images" often published) are along the way. Double check this, if you wish to visit the bells lookout - I don't think you can drive up there as I think they have moved to using a bus system as it is too popular for the parking space available (but I could be mistaken).http://en.wikipedia.org/wiki/Maroon_Bellshttp://allisonandjoshua.files.wordpress.com/2012/07/bells.jpg